Imipenem/Cilastatin
A to Z Drug Facts
Imipenem/Cilastatin |
(ih-mih-PEN-em-SIGH-luh-STAT-in) |
Primaxin IV, Primaxin IM |
Class: Anti-infective/Carbapenem |
Action Imipenem inhibits bacterial cell wall synthesis. Cilastatin prevents metabolism of imipenem, resulting in increased urinary recovery and decreased renal toxicity.
Indications Treatment of serious infections of lower respiratory tract and urinary tract, intra-abdominal and gynecologic infections, bacterial septicemia, bone and joint infections, skin and skin structure infections, endocarditis, and polymicrobic infections due to susceptible microorganisms.
Contraindications IM use with hypersensitivity to local anesthetics of amide type or with severe shock or heart block. IV use with patients with meningitis (safety and efficacy have not been established).
ADULTS: IV 125, 250, or 500 mg dose over 20 to 30 min. Infuse a 750 mg or 1 g dose over 40 to 60 min. If nausea develops, slow the infusion rate. Max: 50 mg/kg/day or 4 g/day, whichever is lower. ADULTS: IM 500 to 750 mg q 12 hr. Max: 1500 mg/day. CHILDREN < 40 kg: IM 60 mg/kg/day. CHILDREN ³ 40 kg: IM Adult dose. PREMATURE INFANTS (³ 36 WK GESTATIONAL AGE): IM 20 mg/kg q 12 hr.
Interactions Cyclosporine: CNS side effects (eg, myoclonia, seizures) may be increased. Ganciclovir: Generalized seizures may occur; avoid use. Probenecid: Minimal increases in imipenem levels and half-life; do not give probenecid concurrently. INCOMPATIBILITIES: Do not physically mix imipenem-cilastatin with other antibiotics.
Lab Test Interferences May cause positive Coombs' test results.
CV: Hypotension; palpitations; tachycardia; phlebitis; thrombophlebitis. CNS: Seizures. GI: Nausea; diarrhea; vomiting; pseudomembranous colitis; hemorrhagic colitis; hepatitis. GU: Presence of RBCs, WBCs, casts and bacteria in urine; increased BUN and creatinine. HEMA: Decreased Hgb and Hct; eosinophilia; increased or decreased WBCs and platelets; decreased erythrocytes. HEPA: Increased AST, ALT, alkaline phosphatase, and bilirubin. OTHER: Pain at injection site.
Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy in children < 12 yr not established with IM use. IV use in neonates to 16 yr (with non-CNS infections) is supported by evidence from adequate and well-controlled studies. IV use is not recommended in pediatric patients with CNS infections because of the risk of seizures, or in pediatric patients < 30 kg with impaired renal function as no data are available. Benzyl alcohol: as a preservative has been associated with toxicity in neonates, especially those < 3 mo. Do not use diluents containing benzyl alcohol when IV is constituted for adminstration to pediatric patients. CNS: IV administration may result in myoclonic activity confusional states or seizures. Hypersensitivity: Administer drug with caution to penicillin-sensitive patients due to possible cross-activity. Pseudomembranous colitis: Consider possibility in patients with diarrhea. Renal impairment: Dosage reduction or alteration of dosage interval is required. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible organisms.
PATIENT CARE CONSIDERATIONS |
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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts